United have injury concerns over a number of defenders, with Axel Tuanzebe and Phil Jones definitely out and left-backs Luke Shaw and Brandon Williams still doubtful.
Shaw twisted his ankle against Southampton and, while he avoided any damage to his ligaments, the nature of that injury is likely to take longer to heal than Williams's cut to his face.
The latter is not thought to be a concussion concern, meaning that he should be available to return for this match after Solskjaer handed a rare start to Timothy Fosu-Mensah against Crystal Palace.
Diogo Dalot's omission from that match set tongues wagging about his future at the club, but the FA Cup could give him and several other fringe players a chance to start with Solskjaer likely to rest many of the forward players that have led their Premier League revival.
Odion Ighalo is one of those who will be pushing for a start, having scored every time he has been named in the starting XI for the club.
Lampard must also decide to what extent he wants to rotate players in order to keep key men fresh for the top-four race despite having two days more rest than United, but he will still be without injured midfielders N'Golo Kante and Billy Gilmour.
The likes of Barkley, Tammy Abraham, Callum Hudson-Odoi and Mason Mountwill all be pushing for starts too, while Fikayo Tomori is available again after injury.
Both teams are expected to name their back-up goalkeepers, meanwhile, with Argentine duo Sergio Romero and Willy Caballero coming in.
Man Utd possible starting lineup:
Romero; Dalot, Bailly, Maguire, Williams; Matic, Fred; James, Pogba, Rashford; Ighalo
Chelsea possible starting lineup:
Caballero; James, Tomori, Christensen, Emerson; Barkley, Jorginho, Mount; Loftus-Cheek, Abraham, Hudson-Odoi
Head To Head
This will be the fourth meeting between these two sides this season, and Manchester United have won all of the previous three - home and away in the Premier League by a 6-0 aggregate scoreline and a 2-1 triumph to knock the Blues out of the EFL Cup.
Indeed, United are now unbeaten in their last six games against Chelsea across all competitions, stretching back to the FA Cup final between the two sides in 2018.
Chelsea have won four of the last five FA Cup ties between these two clubs, but the overall record in this competition stands at nine wins for United compared to five for Chelsea.